We have recently experienced a clinically atypical case of malignant histiocytosis
involving the spleen, ileum and bone marrow, in a 25, year, old Korean male.
He was admitted to our hospital because of multiple purpuric lesions of skin which
had been appearing since 2 years ago. Physical and laboratory examinations revealed
marked splenomegaly with pancytopenia.
With clinical impression of hypersplenism, splenectomy was performed. During the
operation, the surgeons found a dark red mucosal lesion in the ileum incidentally, to
resect the segment. Microscopic findings of the spleen and the ileal lesion showed
extensive proliferation of atypical histiocytes, many of them phagocytosing nomerous
erythrocytes.
Bone marrow biopsy was done for follow-up study, which showed increased
cellularity with infiltration of atypical histiocytes.
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